The increase in awareness in regards with the benefits of using gene therapy as compared to conventional therapy for the treatment of various diseases and government support to promote gene therapy related research are the major driving factors that are projected to boost the market growth.
Gene-fixing treatments have now cured a number of patients with cancer and rare diseases. Genes are composed of DNA that contains necessary information for making proteins that are vital for the human body to function optimally. Some gene mutations result in these proteins not being made correctly and can lead to genetic disorders. Gene therapy works by repairing, repressing, or replacing dysfunctional genes that cause disease with the aim of reestablishing normal function. Gene therapy is an attractive area for drug development because with the right target and approach, it can address the root cause of a severe disease. For certain disorders where known genetic mutations lead to deficient or non-functional protein production, gene therapy can fix the underlying defect and provide a path to produce the functional protein.
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Gene therapy—the idea of modifying a person’s DNA to treat disease—represents a major shift in medicine. Instead of just treating symptoms like the vast majority of drugs on the market, gene therapy aims to correct the underlying genetic cause of a disease. Doctors and scientists hope these treatments will be a one-shot cure.
Last year, we wrote that 2016 was gene therapy’s most promising year. But 2017 proved to be even bigger. Gene therapy had a hell of a 2017. After decades of promises but failed deliveries, last year saw the field hitting a series of astonishing home runs.
The concept of gene therapy is elegant: like computer bugs, faulty letters in the human genome can be edited and replaced with healthy ones.
But despite early enthusiasm, the field has suffered one setback after another. At the turn of the century, the death of an 18-year-old patient with inherited liver disease after an experimental gene therapy treatment put the entire field into a deep freeze.
But no more. Last year marked the birth of gene therapy 2.0, in which the experimental dream finally became a clinical reality. Here’s how the tech grew into its explosive potential—and a sneak peek at what’s on the horizon for 2018.
The global gene therapy market was valued at $584 million in 2016, and is estimated to reach $4,402 million by 2023, registering a CAGR of 33.3% from 2017 to 2023. Due to the high success rate during the preclinical and clinical trial, gene therapy is gaining popularity. There are many techniques used for gene therapy, for example, a procedure where the mutated gene is being replaced with a healthy gene or inactivation of gene whose function is abnormal.
Tumor suppressor and suicide gene therapy are expected to be a lucrative segment for the market players as they are among the fastest growing segment in the gene therapy market. The therapy involves the introduction of new genes into the tumor cells that help destroy the tumor cells without affecting the neighboring healthy cells.
How Does Gene Therapy Work?
Gene therapy is designed to introduce genetic material into cells to compensate for abnormal genes or to make a beneficial protein. If a mutated gene causes a necessary protein to be faulty or missing, gene therapy may be able to introduce a normal copy of the gene to restore the function of the protein.
A quality that is embedded straightforwardly into a cell more often than not does not work. Rather, a bearer called a vector is hereditarily built to convey the quality. Certain infections are frequently utilized as vectors since they can convey the new quality by contaminating the cell. The infections are adjusted so they can’t cause sickness when utilized as a part of individuals. A few kinds of infection, for example, retroviruses, incorporate their hereditary material (counting the new quality) into a chromosome in the human cell. Different infections, for example, adenoviruses, bring their DNA into the core of the phone, however the DNA isn’t incorporated into a chromosome.
The vector can be infused or given intravenously (by IV) specifically into a particular tissue in the body, where it is taken up by singular cells. On the other hand, an example of the patient’s cells can be evacuated and presented to the vector in a research facility setting. The cells containing the vector are then come back to the patient. On the off chance that the treatment is fruitful, the new quality conveyed by the vector will make a working protein.
Specialists must defeat numerous specialized difficulties previously quality treatment will be a reasonable way to deal with treating ailment. For instance, researchers must discover better approaches to convey qualities and target them to specific cells. They should likewise guarantee that new qualities are absolutely controlled by the body.
The key players operating in the global gene therapy market include Novartis, Kite Pharma, Inc., GlaxoSmithKline PLC, Spark Therapeutics Inc., Bluebird bio Inc., Genethon, Transgene SA, Applied Genetic Technologies Corporation, Oxford BioMedica, and NewLink Genetics Corp.
Other prominent players in the value chain include Amgen, Epeius Biotechnologies, Abeona Therapeutics, Sanofi, UniQure, Juno Therapeutics, Adaptimmune, Celgene, and Advantagene.
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” Leading display manufacturers such as LG, Panasonic, Samsung and Sony have launched their 3D TVs and smartphone products in the market. The surge in 3D entertainment content would drive the adoption of 3D TVs, smartphones and monitors. By 2020, more than 50% of the TVs are expected to be 3D compatible. As a result of which, the TV application would continue to dominate the market.”
Allied Market Research published a report titled “Global 3D Display Market – Size, Industry Analysis, Trends, Opportunities, Growth and Forecast, 2013 – 2020.” The report expects the global 3D display market to attain a value of $112.9 billion by the year 2020 with a CAGR of 26.8% during the period 2014 – 2020. The usage of 3D displays in Smartphone and TV’s would boost up the global 3D display Market. It is estimated that about half of the global TV production would come with 3D display by the year 2013.
Among stereoscopic, HMD and volumetric, auto-stereoscopic and stereoscopic display would remain the most popular choice as a result of their higher usage in monitors, TVs and Smartphone. The LED backlighted LCD technology is commonly utilized for the 3D displays. Since, aforementioned technology is cost effective and efficient agaistn CFL technology, the use of 3D display could experience a rise in its production.
The entertainment & media industry is getting advanced because of climb in 3D substance. The developing number of HD-3D amusements would drive the uptake of 3D screens. Indeed among portable processing gadgets, the late dispatches of 3D tablets, notepad, PCs and laptops by organizations, for example, Samsung, Sony and Dell have increased customer awareness. The 3D open presentations are utilized for signage and publicizing. Understanding the business potential, Sony dispatched its initial 3D presentation keeping in mind the end goal to show FIFA 2010 matches in South Africa.
Driving presentation producers, for example, LG, Samsung, Sony and Panasonic have propelled their 3D TVs and cell phone items in the business sector. The surge in 3D entertainment substance would drive the selection of 3D TVs, cell phones and screens. By 2020, more than half of the TVs are required to be 3D perfect. As an aftereffect of which, the TV application would keep on commanding the business.
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Growth of Power Management Integrated Circuits (PMICs) Market: Industry Analysis and Forecasts 2016 to 2022
“Chinese panel manufacturers are inclined towards adopting PMICs in their products. The sales of semiconductors and embedded devices are expected to grow in countries such as India, China, and Taiwan. Highly efficient, low power consumption devices are expected to witness significant growth in the coming years.”
According to a new report published by Allied Market Research, titled, Power Management Integrated Circuits (PMIC) Market by Product Type and End User: Global Opportunity Analysis and Industry Forecast, 2014-2022, the global power management integrated circuits (PMIC) market was valued at $37,802 million in 2015, and is expected to reach $57,888 million by 2022, growing at a CAGR of 6.1% from 2016 to 2022. The voltage regulators segment is anticipated to dominate the global market during the forecast period. The Asia-Pacific region dominated the global market in 2015, accounting for approximately 46.3% share.
The global PMICs market is expected to witness significant growth during the forecast period, owing to surge in production of automobile & battery supported portable electronic devices, increase in need for better performance efficiency, and rise in concerns associated with the cost incurred for power management solutions. The demand for battery supported devices, such as smartphones, is expected to witness noticeable increase in the coming years, mainly in the Asia-Pacific countries such as India and China. Growing emphasis on consumer electronics industries concerned with semiconductor manufacturing, telecommunication and networking and automotive are expected to boost the growth of PMICs. However, factors such as increasing complexity in designing and developing PMIC architecture and uncertainty in economic stability of the market are expected to hamper the market growth.
The automotive and consumer electronics segment accounted for major share in the global market in 2015, and is expected to maintain this trend during the forecast period. The voltage regulators and integrated ASSP power management ICs segments accounted for 27.00% and 25.01% shares, respectively, in the global market in 2015. These segments are estimated to dominate the global PMICs market during 2016-2022.
The voltage regulators, integrated ASSP power management ICs, and battery management ICs segments jointly accounted for around 73.62% of the total share in the overall power management integrated circuits market in 2015. Voltage regulator, which is a major voltage fluctuation measurement component, captured the largest market share of 27.00% in the global market in 2015, with a market value of $10,206 million. This segment is estimated to grow at a CAGR of 6.45% during the forecast period. Voltage regulators are primarily used in electronics devices to ensure constant output level of voltage in spite of the fluctuations in input supply or current. They are used in various application areas such as automation, data processing, lighting, and among others. Furthermore, these devices play a crucial role in power supply systems. They are followed by integrated ASSP power management, a semiconductor embedded device designed for application-specific functioning. Integrated ASSP PMICs accounted for the second largest market share in the global market in 2015.
The automotive and consumer electronics segments are expected to dominate the global market during the forecast period. These segments are projected to grow at CAGRs of 6.16% and 6.42%, respectively. Changing demographics, such as increase in population and growth in disposable income of customers are expected to drive the power management integrated circuits market in the coming years.
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The Asia-Pacific power management integrated circuit market is expected to witness lucrative growth opportunities during the forecast period. Asia-Pacific is one of the fastest growing markets for PMIC, registering a CAGR of 6.74% from 2016 to 2022. The Asia-Pacific PMIC market is projected to account for about 48.19% of the global market share by 2022. The global market is driven by increase in consumer electronics production, technological advancements, and rise in demand for automobile. Japan, South Korea, China, and India are the major revenue contributor to the global market.
Key Findings of the Power Management Integrated Circuits (PMIC) Market
- In 2015, voltage regulators segment dominated the global PMIC market, accounting for around 27.00% revenue share.
- The automotive/transportation segment is expected to dominate the global market throughout the forecast period.
- The consumer electronics segment is anticipated to grow at the highest CAGR of 6.42% during the forecast period.
- The Asia-Pacific region dominated the global PMIC market in 2015, with China being the market leader.
The key players profiled in the global PMIC market report include Texas Instruments Inc. (U.S.), ON Semiconductor Corp. (U.S.), Renesas Electronics Corp. (Japan), Infineon Technologies AG (Germany), Mitsubishi Group (Japan), Maxim Integrated Products Inc. (U.S.), and STMicroelectronics N.V. (Switzerland), and Toshiba Corp (Japan).
According to a new report published by Allied Market Research titled, UK IVF Services Market by End User and Cycle Type: Opportunity Analysis and Industry Forecast, 2014-2022, the UK IVF services market is estimated to reach $685.4 million by 2022, registering a CAGR of 7.7% from 2016 to 2022.
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The UK IVF services market is characterized by important factors such as increase in cases of infertility, delayed marriages, and parenthood decisions. In addition, decrease in birthrate also boost the market growth. For instance, in 2014 total fertility rate decreased to 1.83 per woman from 1.85 in 2013. The IVF services market in the UK is anticipated to experience a continuous growth due to supportive regulatory bodies such as Human Fertilization and Embryo authority (HFEA), which closely regulates the functioning of IVF treatments and research involving human embryos in the UK supplements the market growth. The growth of the market is associated with decrease in birthrate, increase in infertility, and supportive regulations for IVF treatments.
The fertility clinics segment is anticipated to dominate the market during the forecast period in terms of volume and revenue. This is because the fertility clinics provide technologically advanced and wide range of fertility treatments under one roof for patients.
Key Findings of the UK IVF Services Market:
- Based on cycle type, fresh IVF cycles (non-donor) is projected to be one of the fastest growing segment at a CAGR of 8.3% from 2016 to 2022, in terms of revenue
- Based on end users, fertility clinics is projected to be the one of the fastest growing segment at a CAGR of 8.9% from 2016 to 2022, in terms of revenue
- Based on cycle type, fresh IVF cycle (non-donor) is projected to be the one of the fastest growing segment at a CAGR of 7.6% from 2016 to 2022, in terms of volume
- Based on end users, fertility clinics is projected to be the one of the fastest growing segment at a CAGR of 8.2% from 2016 to 2022, in terms of volume
Key players in the UK IVF services market includes companies, hospitals, surgical centers, fertility centers, and clinical research institutes. These includes Lister Fertility Clinics, The Bridge center, and Chelsea and Westminster Hospital.
Increased application of nanocoatings in electronics and automobile industries is expected to offer lucrative opportunities for the global nanocoatings market. Asia-Pacific dominated the market in 2015 due to rise in disposable income resulting in the high standard of living.
Nanocoatings Market Report, published by Allied Market Research, projects that the global market was valued at $3,327 million in 2015, and is expected to reach $13,094 million by 2022, growing at a CAGR of 21.0% during the forecast period. The self-cleaning (bionic & photocatalytic) segment was the largest contributor to the global nanocoatings market in 2015. In the same year, North America held the leading position, and is expected to continue its dominance in the future.
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Nanocoatings offer various benefits such as protection from whether conditions, abrasion resistance, and UV resistance, thus fueling their adoption globally. Self-cleaning segment (bionic & photocatalytic) generated the highest revenue in 2015, as these type of nanocoatings possess the ability to clean themselves by undergoing chemical changes. They are made up of nanoparticles that show super-hydrophilic and super-hydrophobic surfaces, which offer them the self-cleaning ability.
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The electronics segment accounted for the highest revenue in 2015, as electronic components need to be protected from environmental conditions that may reduce their efficiency. These nanocoatings are also used in applications such as the automotive, textile, and construction industries, owing to their anticorrosion, anti-microbial, and easy cleaning properties.
Key Findings of the Nanocoatings Market:
• The electronics application occupied the highest share in 2015, and is expected to grow at a CAGR of 21.0%, in terms of value, during the forecast period.
• North America is the leading consumer of nanocoatings, accounting for approximately more than two-fifths share of the global market, followed by Europe.
• Anticorrosion segment is expected to witness the highest CAGR of 36.4% during the forecast period.
• Automotive & construction segment accounted for one-fourth of the global nanocoatings market in 2015.
• U.S. is the leading market in North American, growing at a CAGR 21.4%.
North America accounted for the largest market share in 2015, whereas Asia-Pacific is projected to grow at the highest CAGR of 23.3% during the forecast period. Utilization of nanocoatings for the prevention of infections due to unhealthy surroundings is expected to increase the demand for nanocoatings from the healthcare industry. Steady growth in the automotive and construction industries in China and India is expected to increase the demand for nanocoatings in the Asian market.
The prominent players profiled in this report include Buhler AG, Nanogate AG, Nanophase Technologies Corporation, Bio-Gate AG, Admat Innovations, Surfix BV, Nanomech Inc., EIKOS Inc., CIMA Nanotech, and Duraseal Coatings Company LLC.
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Upsurge in demand for smart polymers in numerous applications (owing to its exclusive environmental responsive property and increasing research activities) are the prime drivers of the market. However, high cost associated with the use of smart polymers is projected to hamper the market growth during the forecast period.
Smart Polymers Market Report, published by Allied Market Research, projects that the global market was valued at $1,250 million in 2015, and is estimated to reach $3,070 million by 2022, growing at a CAGR of 12.6% from 2016 to 2022. In 2015, physical stimuli responsive segment held almost half of the share of the total market.
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Smart polymer is a subject of great interest for institutional and industrial research. Properties of these polymers such as shape, mechanical properties, phase separation, permeability, and electrical properties changes in response to small variation in environmental conditions. These polymers are widely used in biomedical & biotechnology applications such as drug delivery, tissue engineering, and cell culture support. The extensive research and novel qualities of these polymers has shown significant growth in the market, and is expected to provide lucrative opportunity in the near future.
The growth of the global smart polymers market is driven by the rise in need for efficient & economical drug delivery system, innovative use of smart polymers in the automobile industry, and significant reversible phase transition property of smart polymers. Development of smart polymers from renewable feedstock and increase in awareness about smart polymers in future are expected to provide significant growth opportunities to the industry players. However, high R&D cost increases the overall cost of smart polymers, which is anticipated to hamper the market growth during the forecast period.
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Physical stimuli responsive is the leading segment which are sensitive to environmental factors such as temperature, light, electric field, magnetic field, and mechanical stress, which are widely used as safe polymers in drug delivery and biomaterials.
Shape memory polymer type segment generated the highest revenue in 2015, with almost half of the total market share, followed by self-healing polymer segment. Shape memory polymers retain their original shape at the culmination of the environmental stimulus. These polymers are used in wide range of applications such as surgical fixation, telecommunication, clothing, automotive, and robotics.
Biomedical & biotechnology application segment dominated the global market with more than two-fifths of the global smart polymers share in 2015. Smart polymers are used in multiple biomedical applications such as drug delivery, tissue engineering, bio-separation, biocatalyst, and others.
Key Findings of the Smart Polymers Market:
• In 2015, North America dominated the global market with around one-third of the share, in terms of revenue.
• Chemical stimuli responsive segment is estimated to display the highest growth rate, in terms of revenue, registering a CAGR of 12.8% from 2016 to 2022.
• Asia-Pacific is projected to grow at a highest CAGR of 13.4%, in terms of volume.
• Textile application segment is projected to grow at a highest CAGR of 13.0%, in terms of revenue.
• Self-healing type segment shows the highest growth rate, in terms of revenue, registering a CAGR of 12.9%.
In 2015, North America was the leading region, owing to the increase in research activities and growth in technological advancement for biomedical application. Furthermore, Asia-Pacific is projected to show the highest CAGR of 12.8%, followed by Europe at a CAGR of 12.7% from 2016 to 2022.
The major companies profiled in the report include Covestro AG, BASF SE, Saudi Arabia Basic Industries Corporation (SABIC), Akzonobel, Nippon Shokubai, FMC Corporation, Autonomic Materials Inc., Advanced Polymer Materials Inc., Lubrizol Corporation, and Nexgenia Corporation.
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