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Gene Therapy Had a Breakthrough 2017—2018 May Be Even Better

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The increase in awareness in regards with the benefits of using gene therapy as compared to conventional therapy for the treatment of various diseases and government support to promote gene therapy related research are the major driving factors that are projected to boost the market growth.

Gene-fixing treatments have now cured a number of patients with cancer and rare diseases. Genes are composed of DNA that contains necessary information for making proteins that are vital for the human body to function optimally. Some gene mutations result in these proteins not being made correctly and can lead to genetic disorders. Gene therapy works by repairing, repressing, or replacing dysfunctional genes that cause disease with the aim of reestablishing normal function. Gene therapy is an attractive area for drug development because with the right target and approach, it can address the root cause of a severe disease. For certain disorders where known genetic mutations lead to deficient or non-functional protein production, gene therapy can fix the underlying defect and provide a path to produce the functional protein.

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Gene Therapy- AMR

Gene therapy—the idea of modifying a person’s DNA to treat disease—represents a major shift in medicine. Instead of just treating symptoms like the vast majority of drugs on the market, gene therapy aims to correct the underlying genetic cause of a disease. Doctors and scientists hope these treatments will be a one-shot cure.

Last year, we wrote that 2016 was gene therapy’s most promising year. But 2017 proved to be even bigger. Gene therapy had a hell of a 2017. After decades of promises but failed deliveries, last year saw the field hitting a series of astonishing home runs.

The concept of gene therapy is elegant: like computer bugs, faulty letters in the human genome can be edited and replaced with healthy ones.

But despite early enthusiasm, the field has suffered one setback after another. At the turn of the century, the death of an 18-year-old patient with inherited liver disease after an experimental gene therapy treatment put the entire field into a deep freeze.

But no more. Last year marked the birth of gene therapy 2.0, in which the experimental dream finally became a clinical reality. Here’s how the tech grew into its explosive potential—and a sneak peek at what’s on the horizon for 2018.

The global gene therapy market was valued at $584 million in 2016, and is estimated to reach $4,402 million by 2023, registering a CAGR of 33.3% from 2017 to 2023. Due to the high success rate during the preclinical and clinical trial, gene therapy is gaining popularity. There are many techniques used for gene therapy, for example, a procedure where the mutated gene is being replaced with a healthy gene or inactivation of gene whose function is abnormal.

Tumor suppressor and suicide gene therapy are expected to be a lucrative segment for the market players as they are among the fastest growing segment in the gene therapy market. The therapy involves the introduction of new genes into the tumor cells that help destroy the tumor cells without affecting the neighboring healthy cells.

How Does Gene Therapy Work?

Gene therapy is designed to introduce genetic material into cells to compensate for abnormal genes or to make a beneficial protein. If a mutated gene causes a necessary protein to be faulty or missing, gene therapy may be able to introduce a normal copy of the gene to restore the function of the protein.

A quality that is embedded straightforwardly into a cell more often than not does not work. Rather, a bearer called a vector is hereditarily built to convey the quality. Certain infections are frequently utilized as vectors since they can convey the new quality by contaminating the cell. The infections are adjusted so they can’t cause sickness when utilized as a part of individuals. A few kinds of infection, for example, retroviruses, incorporate their hereditary material (counting the new quality) into a chromosome in the human cell. Different infections, for example, adenoviruses, bring their DNA into the core of the phone, however the DNA isn’t incorporated into a chromosome.

The vector can be infused or given intravenously (by IV) specifically into a particular tissue in the body, where it is taken up by singular cells. On the other hand, an example of the patient’s cells can be evacuated and presented to the vector in a research facility setting. The cells containing the vector are then come back to the patient. On the off chance that the treatment is fruitful, the new quality conveyed by the vector will make a working protein.

Specialists must defeat numerous specialized difficulties previously quality treatment will be a reasonable way to deal with treating ailment. For instance, researchers must discover better approaches to convey qualities and target them to specific cells. They should likewise guarantee that new qualities are absolutely controlled by the body.

The key players operating in the global gene therapy market include Novartis, Kite Pharma, Inc., GlaxoSmithKline PLC, Spark Therapeutics Inc., Bluebird bio Inc., Genethon, Transgene SA, Applied Genetic Technologies Corporation, Oxford BioMedica, and NewLink Genetics Corp.

Other prominent players in the value chain include Amgen, Epeius Biotechnologies, Abeona Therapeutics, Sanofi, UniQure, Juno Therapeutics, Adaptimmune, Celgene, and Advantagene.
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Nurture is as important as nature when it comes to IVF, scientists find…

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UK IVF Services Market

According to a new report published by Allied Market Research titled, UK IVF Services Market by End User and Cycle Type: Opportunity Analysis and Industry Forecast, 2014-2022, the UK IVF services market is estimated to reach $685.4 million by 2022, registering a CAGR of 7.7% from 2016 to 2022.

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The UK IVF services market is characterized by important factors such as increase in cases of infertility, delayed marriages, and parenthood decisions. In addition, decrease in birthrate also boost the market growth. For instance, in 2014 total fertility rate decreased to 1.83 per woman from 1.85 in 2013. The IVF services market in the UK is anticipated to experience a continuous growth due to supportive regulatory bodies such as Human Fertilization and Embryo authority (HFEA), which closely regulates the functioning of IVF treatments and research involving human embryos in the UK supplements the market growth. The growth of the market is associated with decrease in birthrate, increase in infertility, and supportive regulations for IVF treatments.

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The fertility clinics segment is anticipated to dominate the market during the forecast period in terms of volume and revenue. This is because the fertility clinics provide technologically advanced and wide range of fertility treatments under one roof for patients.

Key Findings of the UK IVF Services Market:

  • Based on cycle type, fresh IVF cycles (non-donor) is projected to be one of the fastest growing segment at a CAGR of 8.3% from 2016 to 2022, in terms of revenue
  • Based on end users, fertility clinics is projected to be the one of the fastest growing segment at a CAGR of 8.9% from 2016 to 2022, in terms of revenue
  • Based on cycle type, fresh IVF cycle (non-donor) is projected to be the one of the fastest growing segment at a CAGR of 7.6% from 2016 to 2022, in terms of volume
  • Based on end users, fertility clinics is projected to be the one of the fastest growing segment at a CAGR of 8.2% from 2016 to 2022, in terms of volume

Key players in the UK IVF services market includes companies, hospitals, surgical centers, fertility centers, and clinical research institutes. These includes Lister Fertility Clinics, The Bridge center, and Chelsea and Westminster Hospital.

Nanocoatings Industry is Set to Boom in 2022

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Increased application of nanocoatings in electronics and automobile industries is expected to offer lucrative opportunities for the global nanocoatings market. Asia-Pacific dominated the market in 2015 due to rise in disposable income resulting in the high standard of living.

Nanocoatings Market Report, published by Allied Market Research, projects that the global market was valued at $3,327 million in 2015, and is expected to reach $13,094 million by 2022, growing at a CAGR of 21.0% during the forecast period. The self-cleaning (bionic & photocatalytic) segment was the largest contributor to the global nanocoatings market in 2015. In the same year, North America held the leading position, and is expected to continue its dominance in the future.

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Nanocoatings offer various benefits such as protection from whether conditions, abrasion resistance, and UV resistance, thus fueling their adoption globally. Self-cleaning segment (bionic & photocatalytic) generated the highest revenue in 2015, as these type of nanocoatings possess the ability to clean themselves by undergoing chemical changes. They are made up of nanoparticles that show super-hydrophilic and super-hydrophobic surfaces, which offer them the self-cleaning ability.

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The electronics segment accounted for the highest revenue in 2015, as electronic components need to be protected from environmental conditions that may reduce their efficiency. These nanocoatings are also used in applications such as the automotive, textile, and construction industries, owing to their anticorrosion, anti-microbial, and easy cleaning properties.

Key Findings of the Nanocoatings Market:

• The electronics application occupied the highest share in 2015, and is expected to grow at a CAGR of 21.0%, in terms of value, during the forecast period.
• North America is the leading consumer of nanocoatings, accounting for approximately more than two-fifths share of the global market, followed by Europe.
• Anticorrosion segment is expected to witness the highest CAGR of 36.4% during the forecast period.
• Automotive & construction segment accounted for one-fourth of the global nanocoatings market in 2015.
• U.S. is the leading market in North American, growing at a CAGR 21.4%.

North America accounted for the largest market share in 2015, whereas Asia-Pacific is projected to grow at the highest CAGR of 23.3% during the forecast period. Utilization of nanocoatings for the prevention of infections due to unhealthy surroundings is expected to increase the demand for nanocoatings from the healthcare industry. Steady growth in the automotive and construction industries in China and India is expected to increase the demand for nanocoatings in the Asian market.

The prominent players profiled in this report include Buhler AG, Nanogate AG, Nanophase Technologies Corporation, Bio-Gate AG, Admat Innovations, Surfix BV, Nanomech Inc., EIKOS Inc., CIMA Nanotech, and Duraseal Coatings Company LLC.

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It’s Time For New Vision – Smart Polymers Industry On The Move

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Upsurge in demand for smart polymers in numerous applications (owing to its exclusive environmental responsive property and increasing research activities) are the prime drivers of the market. However, high cost associated with the use of smart polymers is projected to hamper the market growth during the forecast period.

Smart Polymers Market Report, published by Allied Market Research, projects that the global market was valued at $1,250 million in 2015, and is estimated to reach $3,070 million by 2022, growing at a CAGR of 12.6% from 2016 to 2022. In 2015, physical stimuli responsive segment held almost half of the share of the total market.

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Smart polymer is a subject of great interest for institutional and industrial research. Properties of these polymers such as shape, mechanical properties, phase separation, permeability, and electrical properties changes in response to small variation in environmental conditions. These polymers are widely used in biomedical & biotechnology applications such as drug delivery, tissue engineering, and cell culture support. The extensive research and novel qualities of these polymers has shown significant growth in the market, and is expected to provide lucrative opportunity in the near future.

The growth of the global smart polymers market is driven by the rise in need for efficient & economical drug delivery system, innovative use of smart polymers in the automobile industry, and significant reversible phase transition property of smart polymers. Development of smart polymers from renewable feedstock and increase in awareness about smart polymers in future are expected to provide significant growth opportunities to the industry players. However, high R&D cost increases the overall cost of smart polymers, which is anticipated to hamper the market growth during the forecast period.

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Physical stimuli responsive is the leading segment which are sensitive to environmental factors such as temperature, light, electric field, magnetic field, and mechanical stress, which are widely used as safe polymers in drug delivery and biomaterials.

Shape memory polymer type segment generated the highest revenue in 2015, with almost half of the total market share, followed by self-healing polymer segment. Shape memory polymers retain their original shape at the culmination of the environmental stimulus. These polymers are used in wide range of applications such as surgical fixation, telecommunication, clothing, automotive, and robotics.

Biomedical & biotechnology application segment dominated the global market with more than two-fifths of the global smart polymers share in 2015. Smart polymers are used in multiple biomedical applications such as drug delivery, tissue engineering, bio-separation, biocatalyst, and others.

Key Findings of the Smart Polymers Market:

• In 2015, North America dominated the global market with around one-third of the share, in terms of revenue.
• Chemical stimuli responsive segment is estimated to display the highest growth rate, in terms of revenue, registering a CAGR of 12.8% from 2016 to 2022.
• Asia-Pacific is projected to grow at a highest CAGR of 13.4%, in terms of volume.
• Textile application segment is projected to grow at a highest CAGR of 13.0%, in terms of revenue.
• Self-healing type segment shows the highest growth rate, in terms of revenue, registering a CAGR of 12.9%.

In 2015, North America was the leading region, owing to the increase in research activities and growth in technological advancement for biomedical application. Furthermore, Asia-Pacific is projected to show the highest CAGR of 12.8%, followed by Europe at a CAGR of 12.7% from 2016 to 2022.

The major companies profiled in the report include Covestro AG, BASF SE, Saudi Arabia Basic Industries Corporation (SABIC), Akzonobel, Nippon Shokubai, FMC Corporation, Autonomic Materials Inc., Advanced Polymer Materials Inc., Lubrizol Corporation, and Nexgenia Corporation.

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Global Warehouse Management System Market to Garner $3,112 Million, by 2022

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Warehouse Management System Market Report, published by Allied Market Research, forecasts that the global market size is expected to garner $3,112 million by 2022, growing at a CAGR of 15.2% during the period 2016-2022. This can be attributed to the increase in inventory and workload of WMS in warehouse operations. Europe is expected to be the largest market during the forecast period.

By component type, software held the highest marketsharein2015, and services is anticipated to show the highest growth rate. Among the various industry verticals, transportation & logistics is projected to dominate the market. However, pharmaceuticals industry is expected to have the fastest growth rate.

Asia-Pacific is estimated to grow fastest due to increase in the adoption of WMS services and extensive growth in Japan, China, Australia, and India.

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Fig.  WMS Market segmentation

Improved supplier and customer relationships
WMS reduces the delivery lead times and errors while processing the orders. The suppliers seek greater efficiency and productivity while implementing WMS, which strengthens the supplier‐customer relationships, and is a notable driver for the WMS market. The impact of this factor was remarkable during 2015, and is projected to significantly rise over the forecast period.

Costly deployment of WMS solutions

Inherent challenges associated with implementation of the distribution software such as lack of process standardization in distribution, less business savvy users, high rate of simultaneous active transactions, materials handling interface requirements, and other factors result in resource monopolization, cost overruns, and operational disruption risks. Smaller facilities with lower headcounts find WMS solutions too expensive to deploy. Many such firms rely on memory-based processes, antiquated systems, and paper-based warehouse operations. In the year 2015, the impact of this factor was prominent; however, due to technological advancements, this impact is predicted to decline over the forecast period.

Emergence of SaaS-based on-demand WMS solutions
The smaller firms and other companies seek for less capital investments and greater flexibility. The on-demand supply chain execution is expected to gain larger share of the market over the forecast period. Smart Turn, a WMS vendor, was among the first companies to promote this model. Several suppliers have provided their software as a service to get a foothold in the market. The impact of this factor was notable in 2015, and is expected to increase over the forecast period.

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 Key findings of the Warehouse Management System Market:

  • Software is expected to exhibit a significant growth in the WMS market due to growth in adoption of this technology in the logistics industry.
  • Transportation & logistics industry generated the highest revenue among other industry verticals pertaining to increase in adoption of WMS.
  • Europe is projected to exhibit a substantial growth during the forecast period.
  • Several industry players adopt partnership and product launch as their key strategies to offer innovative products and services & solutions to attain a higher market share.
  • The dominant players include Oracle Corporation, SAP SE, Infor Inc., and Manhattan Associates Inc., and others.

 

Automated Material Handling Equipment Market to Reach $39,060 Million Globally, by 2022

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Automated Material Handling Equipment Market: Global Opportunity Analysis and Industry Forecast, 2014 – 2022, projects that the global automated material handling equipment market size is expected to reach $39,060 million by 2022. Robotic systems dominated the global market in 2015, and is expected to maintain this trend from 2016 to 2022. Europe is expected to dominate the market throughout the forecast period due to increase in demand for automated technologies in manufacturing industries.

Automated material handling equipment (for example robotics systems) witnessed a higher demand owing to increased need for automation in industries, such as e-commerce, automotive and food & beverages due to reduced operational costs, improved supply chain process, and reduced labor costs. Moreover, technological advancements such as the introduction of vision guided navigation technology, which allows the vehicle to follow the route without any human intervention, has further strengthened the market growth for automated transport equipment. In addition, the demand for energy efficient and eco-friendly robotics systems are expected to increase the demand for automated material handling equipment. However, high initial installation costs of such systems could hamper their market growth.

Major types of automated material handling equipment sought by the customer industries include automated guided vehicles, automated storage & retrieval systems, automated crane, robotics systems, and automated conveyor & sortation systems. Robotics systems constitute the highest market share of 30.7% in 2015 owing to high accuracy, superior efficiency, and reduction in product damage offered by pick and place robot systems. Automated conveyor systems accounted for one fifth of the market share in 2015, and is likely to reach $7,596 million by 2022 at a CAGR of 6.5%.

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Automated materials handling systems are used in various applications such as assembly, transportation, distribution, storage, and waste handling. Among these, storage application accounted for the largest market share in material handling equipment industry accounted for around 26.2% market share in 2015. Storage systems are space efficient, increases storage capacity, and improves inventory control system.

Based on system type, the AMH equipment market is divided into unit load material handling system and bulk load material handling system. Unit load material handling system accounted for the largest share of more than 63% in 2015 as this system is easy to install and provides high return on investment.

Among the major industry verticals, the automated materials handling systems find widespread usage in the automotive industry. Automotive industry accounted for more than 26% share of the global market in 2015 owing to increased automobile production in China, Japan, and India. This segment is estimated to witness significant growth during the forecast period due to improving production processes, lowering labor intensity, and timely delivery of materials.

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Software component is projected to grow rapidly, registering a CAGR of 8.2% during the forecast period due to increased usage of warehouse control system as it reduces the rate of missing stock, improve handling rates, and maintain high service level. Market players offer wide variety of software and control systems, effective for warehouse and manufacturing facilities. For instance, Daifuku Co. Ltd. introduced warehouse control system that provides high efficiency and accuracy.

Europe region accounted for the maximum market share in 2015, and is expected to maintain its lead throughout the forecast period. This is attributed to heavy investment by automotive and food & beverage industry players in automation. LAMEA region has exhibited significant growth due to rapid industrialization. Especially, emerging countries such as Brazil facilitates the market growth.

Global Service Robotics Market is Expected to Reach $34.7 Billion by 2022 – Allied Market Research

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Global Service robotics market is expected to reach $34.7 billion by 2022, with a CAGR of 23.9% from 2015 to 2022, according to a new report by published by Allied Market Research. The growing need of automation across various industries has encouraged organizations to adopt service robotics for increased productivity, superior quality and precise operations, reduced operation costs, and enhanced safety of workforce. Increasing labor costs coupled with lack of workforce further accelerate the growth of market.

Increasing need for safety along with government regulations for labor protection drives organizations to adopt service robotics for enhanced safety at workplace. The growing penetration of mobile devices facilitates the development of advanced robotic systems and boosts the growth of market. Vendors in the market focus on developing affordable and energy-efficient robots for small and medium enterprises to cater to the growing requirements of consumers. The significant rise in investments in R&D for the development of service robots along with the establishment of organizations including Standardized Procedures for the Advancement of Robotic Combat (SPARC) and International Federation of Robotics (IFR), further fosters the growth of the market.

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Professional service robots are used in healthcare; defense, rescue, and security; field; logistics; and construction industries. The segment of professional service robotics generated $3.9 billion in 2014 owing to high demand of automation from these sectors. Reduction in labor costs, increased operational efficiency, and delivery of high-quality services with improved precision and accuracy further encourages consumers to employ professional service robots. The revenue of personal service robotics segment is expected to grow at a rate of over 26% during the forecast period, owing to high demand of service robots from the domestic and entertainment sectors and rise in disposable income of consumers. In terms of volume, personal robots accounted for a higher share and generated over 4,672 thousand units in 2014.

Healthcare is the major end user industry, in terms of revenue generation, that employs service robots for a wide range of applications such as surgery, diagnostics, physical and mental therapy, and prosthetics among others. Patient monitoring, laboratory automation, drug discovery, and prescription preparation are other applications of service robotics in the healthcare sector. It accounted for over 35% share of the global market revenue in 2014, followed by defense, rescue and security sector.

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Other industries utilizing service robotics include field, logistics, construction, domestic, and entertainment. The construction industry is likely to grow at the highest CAGR during the forecast period. In terms of volume, defense, rescue, & security robots accounted for the highest share and generated around 11 thousand units in 2014 owing to the increased employment of unmanned aerial vehicles, unmanned ground vehicles, firefighting & disaster management robots, professional surveillance robots, and demining robots. The healthcare segment is forecast to grow at the highest CAGR of 29.1% during 2015-2022 in terms of volume.

Key findings of Service Robotics Market:

  • The service robotics market is projected to exhibit a significant growth owing to increasing demand of automation from various industries, rising application areas, and growth in emerging economies.
  • The professional robotics segment is anticipated to dominate the market in terms of revenue owing to the increasing applications from healthcare, defense, rescue and security, agriculture, logistics, and construction industries.
  • The healthcare industry is excepted to maintain its leading position in the market during the forecast period in terms of revenue.
  • Europe is likely to dominate the market throughout the forecast period.

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Allied Market Research (AMR) is a full-service market research and business-consulting wing of Allied Analytics LLP based in Portland, Oregon. Allied Market Research provides global enterprises as well as medium and small businesses with unmatched quality of “Market Research Reports” and “Business Intelligence Solutions”. AMR has a targeted view to provide business insights and consulting to assist its clients to make strategic business decisions and achieve sustainable growth in their respective market domain.

We are in professional corporate relations with various companies and this helps us in digging out market data that helps us generate accurate research data tables and confirms utmost accuracy in our market forecasting. Each and every data presented in the reports published by us is extracted through primary interviews with top officials from leading companies of domain concerned. Our secondary data procurement methodology includes deep online and offline research and discussion with knowledgeable professionals and analysts in the industry.

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